ABOUT PONICIDIN

TAK-243 preferentially certain to UBA1 in excess of the connected E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 reduced levels of ubiquitylated proteins, improved markers of proteotoxic anxiety and DNA problems pressure. In vivo, TAK-243 reduced leukemic load and focused leukemic stem cells with out evidence o